Adjuvant Therapy

Use of Intera 3000 Hepatic Artery Infusion Pump for patients with resected Colorectal Liver Metastases (CLM) (adjuvant therapy):

2,368 patients who underwent complete resection of CLM at Memorial Sloan Kettering were consecutively enrolled in a prospectively maintained database.

  • Patients who received the Intera 3000 HAI Pump plus systemic chemotherapy had a median overall survival of 67 months. Patients who received systemic chemotherapy alone had a median survival of 47 months (P<0.001).
  • In propensity score analysis, the same strong association with overall survival was found with an adjusted hazard ratio for HAI of 0.67 (P < 0.001).
  • Patients who received the Intera 3000 HAI Pump plus systemic chemotherapy had overall survival of 52.9% at 5 years versus overall survival of 37.9% with systemic chemotherapy alone (P<0.001). 
  • Patients who received the Intera 3000 HAI Pump plus systemic chemotherapy had overall survival of 38.0% at 10 years versus overall survival of 23.8% with systemic chemotherapy alone (P<0.001).
  • Use of the Intera 3000 HAI Pump was not associated with increased overall survival in patients with extrahepatic disease, a positive resection margin, or a clinical risk score of 4 or 5. Overall survival for patients in this study who did not receive the Intera 3000 HAI Pump was similar to overall survival in other large studies without the Intera 3000 HAI Pump.
Adjuvant Therapy

Study limitations: this study was not a randomized, controlled trial therefore unmeasured prognostic factors could be unbalanced across treatment groups and partly explain the difference in overall survival. The study covers a period of 21 years including the introduction of irinotecan, oxaliplatin, and targeted treatments. [1]

[1]  Koerkamp BG, Sadot E, Kemeny NE, et al : Perioperative Hepatic Arterial Infusion Pump Chemotherapy

Is Associated With Longer Survival After Resection of Colorectal Liver Metastases: A Propensity Score Analysis. J Clin Oncol 35. © 2017 by American Society of Clinical Oncology

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